en آسيب شناسي Pathology Research Article Research Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><span style="line-height:200%"><span new="" roman="" times=""><b>Background:</b> Granulomatous<b> </b>disorders of the skin are frequently encountered in clinical practice and require histopathological confirmation due to a considerable etiological and clinical overlap. A single histopathological pattern may be produced by many causative agents and at the same time, a single cause can present with varied histopathological patterns. The present study was performed to evaluate the histomorphological patterns of granulomas in various granulomatous skin lesions and to identify the causative agents.</span></span><br> <span style="line-height:200%"><span new="" roman="" times=""><b>Methods:</b> The study (both prospective and retrospective) was carried out in the department of pathology over 5 years. All skin biopsies were evaluated for the presence of granulomas. Detailed analysis of the histopathological pattern of granulomas was performed and categorization was made according to the type and etiology. Special stains were also used when required. A clinicopathological correlation was established with <span style="background:white"><span style="color:black">the Kappa statistic. </span></span><span style="background:white"></span></span></span><br> <span style="line-height:200%"><span new="" roman="" times=""><b>Results:</b> Of 1,150 skin biopsies, granulomatous skin lesions were observed in 325 cases. Histiocytic granuloma pattern was the most common subtype (55.7%). The predominant etiology of granulomatous inflammation was leprosy (93.5%), followed by cutaneous tuberculosis (2.7%). The cases of Hansen&rsquo;s disease showed a maximum clinicopathological correlation (58.5%).</span></span><br> <span style="line-height:200%"><span new="" roman="" times=""><b>Conclusion:</b> <span style="background:white"><span style="color:black">Histopathological examination is the gold standard for the diagnosis and subtyping of granulomatous skin lesions. Varied morphologies of granuloma patterns were observed in our study, and i</span></span>nfectious diseases were the causative agents in the majority of cutaneous granulomatous disorders.&nbsp;</span></span></span></span></div> Granuloma,Leprosy,Tuberculosis, 7 13 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1278-1&slc_lang=en&sid=1 Priyanka Sharma rahulukraine@gmail.com No Department of Pathology, Government Medical College, Jammu, India Rahul Verma rahulsrhu@gmail.com 0000-0003-4403-7510 Yes Department of Pathology, AIIMS Rishikesh, India