en باکتری شناسی bacteriology مروري Review Article Increasing antibiotic resistance is a global health problem. In recent years, due to the indiscriminate use of antibacterial compounds, many bacterial pathogens, including staphylococci, members of the <em>Enterobacteriaceae</em> family including <a name="OLE_LINK1"><em>Klebsiella pneumoniae</em></a> and bacteria such as <em>Pseudomonas aeruginosa </em>and <em>Acinetobacter</em> <em>baumannii</em> have become multi-drug resistant. Consequently, it is important to explore alternative approaches for eliminating resistant strains. Bacteria synthesize low-weight molecules called siderophores to chelate iron from the environment as a vital element for their growth and survival. One way to deal with resistant bacterial strains is to utilize siderophore-mediated iron uptake pathways as entrance routes for drug delivery. Therefore, the production of drugs with Trojan horse strategy in the form of conjugated siderophore-antibiotic complexes has recently received much attention <a name="OLE_LINK2"></a><a name="OLE_LINK5">for dealing with resistan</a>t isolates. <a name="OLE_LINK17">In this review, </a>we discuss the efficacy of siderophore-antibiotic conjugates as a Trojan horse strategy for eliminating drug-resistant pathogens. Siderophores,Iron,Drug Delivery Systems,Drug Carriers,Drug resistance,Anti-Bacterial Agents, 44 54 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1006-1&slc_lang=en&sid=1 Behnoush Khasheii bh_kh@yahoo.com 100319475328460021051 100319475328460021051 No Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran Pezhman Mahmoodi mahmoodi_pezhman@@basu.ac.ir 100319475328460021052 100319475328460021052 Yes Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran Abdolmajid Mohammadzadeh 100319475328460021053 100319475328460021053 No Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran